Endocrine Abstracts

Background: Contrast procedures are frequently performed in diabetic patients and are the third most common cause of hospital-acquired renal failure1. Diabetic patients are at risk of Metformin associated lactic acidosis in the presence of renal failure2.Standards: RCR guidelines3 recommend:• Recent serum creatinine should be available for patients with renal disease or diabetes<p class="ab...

Introduction: Adrenocortical carcinoma (ACC) is an uncommon aggressive malignancy. Despite surgical resection, recurrence rates are high. Two areas of contention currently involve treatment of ACC: the role of laparoscopic surgery in removal of large, potentially malignant tumours and the role of Mitotane. We present a case of a large adrenal tumour, later confirmed as ACC, where initially laparoscopic adrenalectomy was considered, and adjuvant Mitotane has been given despite ...

Background and objectives: Goitre is still one of endemic health problems in Gorgan city after one decade of universal salt iodization in Iran. Hypothyroism have different complications in children that between them, developmental disorders of CNS are so important. This study proposed to determine that prevalence of thyroid function and volume disorders and its correlation with IQ in the mental retard (MR) children.Material and methods: This cross-sectio...

The aim of this study was to determine of pregnancy rate when Estradiol Benzoate (EB) used in presynch method than to routine presynchronization protocol in lactating dairy cows (N: 210). In this study, cows divided in two treatment groups: control group (N: 100) and main group (N: 110). Control group cows received two injections of Cloprostenol (750 μg/Case, IM) with 14 d interval. Then, they received an injection of Gonadorelin (100 μg/Case, IM...

Introduction: In the management of patients with differentiated thyroid carcinoma, serum thyroglobulin levels are often well correlated with whole-body radioiodine scanning (WBS) results. However, occasionally, a mismatched result – increased thyroglobulin with negative WBS – is observed. Radioiodine therapy has been suggested as a therapeutic choice with controversial results.Method: We studied 32 differentiated thyroid carcinoma patients with...

Case report: A 40-year-old lady was diagnosed with acromegaly in 1993 after presentation with clinical symptoms. Imaging showed a 1 cm pituitary lesion and she underwent transphenoidal hypophysectomy in 1993. Post-operatively she was rendered hypopituitary, but still had biochemical evidence of active acromegaly. She proceeded to external beam radiotherapy and was started on bromocriptine medical therapy.On routine review in 2006, her acromegaly was bioc...

We present a difficult case of pituitary thyroid hormone resistance (PTHR) in a 6 year old girl. She presented at the age of 22 months with chronic cough, diarrhoea, failure to gain weight and gross motor delay. She was also noted to be hyperactive and clumsy with poor co-ordination. Persistent tachycardia was present on examination. Thyroid function tests revealed increased thyroid hormone concentrations with a free T4 of 63.7 pmol/l (9–25) and a free T3 of 20 pmol/l (3....

Background: Metabolic syndrome not only is a serious problem for adults, but is also afflicting an increasing number of children and adolescents. This syndrome is a risk factor for type 2 diabetes mellitus and cardiovascular diseases. The aim of this study was to estimate the prevalence of metabolic syndrome in a sample of Iranian adolescents.Methods: A total of 554 overweight adolescents (aged 11–17 years) participated in a community-based cross se...

Background: Several cytokines and chemokines are released by adipose tissue and associated with insulin resistance. We investigated the systemic and in vitro release of RANTES(Regulated upon Activation Normal T-cell Expressed and Secreted), MCP-1(Monocyte Chemo-attractant Protein-1), adiponectin, leptin and IL-6 from three human adipose tissue depots and their relationship to insulin sensitivity.Methods: Fasting blood samples were taken from obese...

We report a retrospective study of 50 cases of primary hyperparathyroidism (10 men and 40 women, mean age: 49 years) collected between 1975 and 2004. At the time of diagnosis, 44% of patients had bone disease, renal manifestations were present in 17 cases (34%).Parathyroidectomy is a safe and effective approach of primary hyperparathyroidism treatment. The management of persistent or recurrent hyperparathyroidism is explained by the fact that parathyroid...